| 2. Round | 20/03/2021 | Gimnasia de Jujuy | - | Almagro | 1:2 | ||||
| 4. Round | 03/04/2021 | Barracas Central | - | Almagro | 2:1 | ||||
| 5. Round | 11/04/2021 | Almagro | - | Independiente Rivadavia | 0:2 | ||||
| 7. Round | 24/04/2021 | Almagro | - | Guillermo Brown | 2:2 | ||||
| 8. Round | 30/04/2021 | Brown de Adrogué | - | Almagro | 2:0 | ||||
| 9. Round | 09/05/2021 | Almagro | - | San Martín de San Juan | 0:1 | ||||
| 11. Round | 11/06/2021 | Almagro | - | San Telmo | 1:0 | ||||
| 14. Round | 27/06/2021 | Almagro | - | All Boys | 3:0 | ||||
| 15. Round | 04/07/2021 | Güemes de SdE | - | Almagro | 0:2 |  |
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| 16. Round | 11/07/2021 | Almagro | - | Deportivo Morón | 2:1 | ||||
| 33. Round | 06/11/2021 | Deportivo Morón | - | Almagro | 1:0 |
Argentina