| 1. Round | 07/01/2022 | Pumas Tabasco | - | CF Monterrey II | 0:1 |  |
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| 2. Round | 11/01/2022 | CF Monterrey II | - | Cimarrones de Sonora | 1:0 | ||||
| 3. Round | 23/01/2022 | Atlético Morelia | - | CF Monterrey II | 1:0 | ||||
| 4. Round | 26/01/2022 | CF Monterrey II | - | Alebrijes de Oaxaca | 2:0 | |
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| 5. Round | 30/01/2022 | Club Celaya | - | CF Monterrey II | 2:1 | ||||
| 6. Round | 02/02/2022 | CF Monterrey II | - | Atlante | 0:1 |  |
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| 7. Round | 10/02/2022 | Mineros de Zacatecas | - | CF Monterrey II | 1:0 | ||||
| 8. Round | 16/02/2022 | CF Monterrey II | - | Correcaminos UAT | 3:3 | |
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| 9. Round | 24/02/2022 | Cancún FC | - | CF Monterrey II | 0:0 | ||||
| 10. Round | 03/03/2022 | CF Monterrey II | - | Venados FC | 3:3 | |
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| 11. Round | 09/03/2022 | TM Fútbol Club | - | CF Monterrey II | 0:0 | ||||
| 13. Round | 23/03/2022 | Leones Negros | - | CF Monterrey II | 0:0 | ||||
| 15. Round | 31/03/2022 | Coyotes de Tlaxcala | - | CF Monterrey II | 2:1 | |
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| 16. Round | 08/04/2022 | CF Monterrey II | - | Tepatitlán | 0:2 | ||||
| 12. Round | 10/04/2022 | CF Monterrey II | - | Dorados de Sinaloa | 0:1 | ||||
| 17. Round | 15/04/2022 | Tapatío | - | CF Monterrey II | 1:2 | |
Mexico