| 1. Round | 20/08/2017 | Liverpool | - | River Plate | 0:4 |  |
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| 2. Round | 26/08/2017 | River Plate | - | Boston River | 1:1 |  |
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| 3. Round | 02/09/2017 | Montevideo Wanderers | - | River Plate | 2:2 | |
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| 4. Round | 12/09/2017 | River Plate | - | Nacional | 2:1 | ||||
| 5. Round | 16/09/2017 | Fénix | - | River Plate | 0:0 | ||||
| 6. Round | 23/09/2017 | River Plate | - | Rampla Juniors | 3:1 | |
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| 7. Round | 14/10/2017 | Defensor Sporting | - | River Plate | 2:1 | ||||
| 8. Round | 04/11/2017 | River Plate | - | Sud América | 1:2 | |
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| 10. Round | 11/11/2017 | River Plate | - | Danubio | 1:1 | |
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| 12. Round | 18/11/2017 | CA Cerro | - | River Plate | 2:2 | ||||
| 13. Round | 22/11/2017 | River Plate | - | Peñarol | 2:1 | ||||
| 14. Round | 26/11/2017 | Racing | - | River Plate | 0:0 | ||||
| 15. Round | 03/12/2017 | River Plate | - | El Tanque Sisley | 1:0 |
Uruguay