| 2. Round | 24/01/2020 | San Lorenzo | - | 12 de Octubre de Itauguá | 1:0 | ||||
| 3. Round | 01/02/2020 | Club Olimpia | - | San Lorenzo | 4:2 | ||||
| 4. Round | 08/02/2020 | San Lorenzo | - | Club Nacional | 1:1 | ||||
| 5. Round | 17/02/2020 | River Plate | - | San Lorenzo | 4:2 |  |
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| 6. Round | 24/02/2020 | San Lorenzo | - | Sportivo Luqueño | 0:0 | ||||
| 7. Round | 02/03/2020 | Sol de América | - | San Lorenzo | 2:1 | ||||
| 8. Round | 08/03/2020 | San Lorenzo | - | Guaireña FC | 1:1 | ||||
| 9. Round | 22/07/2020 | General Díaz | - | San Lorenzo | 2:1 | ||||
| 10. Round | 25/07/2020 | San Lorenzo | - | Libertad | 1:2 | ||||
| 11. Round | 02/08/2020 | Cerro Porteño | - | San Lorenzo | 4:1 | ||||
| 13. Round | 13/08/2020 | 12 de Octubre de Itauguá | - | San Lorenzo | 1:0 | ||||
| 14. Round | 17/08/2020 | San Lorenzo | - | Club Olimpia | 2:2 | ||||
| 15. Round | 21/08/2020 | Club Nacional | - | San Lorenzo | 2:0 | ||||
| 16. Round | 26/08/2020 | San Lorenzo | - | River Plate | 0:0 | ||||
| 20. Round | 19/09/2020 | San Lorenzo | - | General Díaz | 2:1 | ||||
| 21. Round | 27/09/2020 | Libertad | - | San Lorenzo | 3:0 | ||||
| 22. Round | 03/10/2020 | San Lorenzo | - | Cerro Porteño | 1:1 | |
Uruguay