| 1. Round | 16/10/2020 | General Díaz | - | San Lorenzo | 0:1 | ||||
| 2. Round | 25/10/2020 | San Lorenzo | - | Club Nacional | 1:1 |  |
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| 3. Round | 01/11/2020 | Club Olimpia | - | San Lorenzo | 3:1 | ||||
| 4. Round | 06/11/2020 | 12 de Octubre de Itauguá | - | San Lorenzo | 0:1 | |
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| 5. Round | 12/11/2020 | San Lorenzo | - | Sportivo Luqueño | 1:2 | ||||
| 6. Round | 16/11/2020 | Guaraní | - | San Lorenzo | 2:1 | |
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| 7. Round | 20/11/2020 | San Lorenzo | - | Libertad | 2:2 | |
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| 8. Round | 27/11/2020 | Guaireña FC | - | San Lorenzo | 2:2 | ||||
| 9. Round | 06/12/2020 | San Lorenzo | - | Sol de América | 2:2 | ||||
| 10. Round | 13/12/2020 | Cerro Porteño | - | San Lorenzo | 1:1 | |
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Uruguay