| 1. Round | 19/09/2020 | Saltillo FC | - | Mineros de Fresnillo FC | 2:2 | ||||
| 2. Round | 25/09/2020 | Mazorqueros | - | Saltillo FC | 1:1 | ||||
| 3. Round | 02/10/2020 | Saltillo FC | - | Atlético San Luis II | 1:3 | ||||
| 6. Round | 25/10/2020 | Tuzos de la UAZ | - | Saltillo FC | 0:0 | ||||
| 5. Round | 31/10/2020 | Saltillo FC | - | Gavilanes de Matamoros | 0:0 | ||||
| 8. Round | 13/11/2020 | Cimarrones de Sonora II | - | Saltillo FC | 0:2 |  |
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| 7. Round | 17/11/2020 | Saltillo FC | - | Alacranes de Durango | 1:2 | ||||
| 4. Round | 29/11/2020 | Reboceros de La Piedad | - | Saltillo FC | 7:0 | ||||
| 10. Round | 05/12/2020 | Saltillo FC | - | Leones Negros II | 2:0 | ||||
| 11. Round | 10/12/2020 | Tecos Fútbol Club | - | Saltillo FC | 0:0 | ||||
| 12. Round | 15/01/2021 | Mineros de Fresnillo FC | - | Saltillo FC | 2:2 | ||||
| 13. Round | 23/01/2021 | Saltillo FC | - | Mazorqueros | 3:2 | ||||
| 14. Round | 29/01/2021 | Atlético San Luis II | - | Saltillo FC | 2:0 | ||||
| 15. Round | 06/02/2021 | Saltillo FC | - | Reboceros de La Piedad | 2:2 | ||||
| 18. Round | 06/03/2021 | Alacranes de Durango | - | Saltillo FC | 3:1 | ||||
| 19. Round | 13/03/2021 | Saltillo FC | - | Cimarrones de Sonora II | 1:0 | ||||
| 20. Round | 20/03/2021 | Saltillo FC | - | Colima FC | 0:1 |
Mexico