| 5. Round | 13/02/2022 | Lobos ULMX | - | Deportivo Dongu | 2:0 |  |
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| 6. Round | 19/02/2022 | Deportivo Dongu | - | Reboceros de La Piedad | 0:4 | ||||
| 7. Round | 26/02/2022 | Deportivo Dongu | - | Inter Playa | 1:4 | ||||
| 8. Round | 05/03/2022 | Cañoneros FC | - | Deportivo Dongu | 1:0 | ||||
| 10. Round | 19/03/2022 | Escorpiones | - | Deportivo Dongu | 5:3 |  |
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| 11. Round | 26/03/2022 | Deportivo Dongu | - | Cafetaleros de Chiapas | 1:2 | ||||
| 12. Round | 03/04/2022 | CD Zap | - | Deportivo Dongu | 2:1 | ||||
| 13. Round | 09/04/2022 | Deportivo Dongu | - | Inter de Querétaro | 6:1 | |
Mexico