| 2. Round | 23/05/2021 | Plaza Colonia | - | Montevideo City Torque | 1:0 |  |
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| 3. Round | 29/05/2021 | Villa Española | - | Plaza Colonia | 1:3 | ||||
| 1. Round | 02/06/2021 | Peñarol | - | Plaza Colonia | 0:0 | ||||
| 4. Round | 05/06/2021 | Plaza Colonia | - | Nacional | 1:2 | |
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| 5. Round | 12/06/2021 | Cerrito | - | Plaza Colonia | 1:2 | ||||
| 6. Round | 17/06/2021 | Plaza Colonia | - | Liverpool | 2:1 | ||||
| 7. Round | 22/06/2021 | River Plate | - | Plaza Colonia | 0:1 | ||||
| 8. Round | 28/06/2021 | Plaza Colonia | - | Cerro Largo | 1:1 | ||||
| 9. Round | 05/07/2021 | Progreso | - | Plaza Colonia | 1:2 |  |
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| 10. Round | 10/07/2021 | Plaza Colonia | - | Sud América | 1:0 | |
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| 11. Round | 17/07/2021 | Deportivo Maldonado | - | Plaza Colonia | 0:1 |
Uruguay