| 2. Round | 03/08/2021 | Atlético San Luis | - | Gallos Blancos | 1:1 |  |
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| 3. Round | 06/08/2021 | Gallos Blancos | - | Club León | 0:1 | |
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| 7. Round | 28/08/2021 | Puebla FC | - | Gallos Blancos | 1:0 | ||||
| 12. Round | 03/10/2021 | Deportivo Toluca | - | Gallos Blancos | 1:1 | ||||
| 14. Round | 19/10/2021 | Gallos Blancos | - | CF Monterrey | 1:0 | ||||
| 17. Round | 05/11/2021 | Atlas Guadalajara | - | Gallos Blancos | 2:0 |
Mexico