| 1. Round | 04/04/2021 | Deportes Iquique | - | Coquimbo Unido | 2:3 | ||||
| 3. Round | 25/04/2021 | Deportes Iquique | - | San Marcos | 1:2 | ||||
| 4. Round | 03/05/2021 | Barnechea | - | Deportes Iquique | 3:1 | ||||
| 5. Round | 09/05/2021 | Deportes Iquique | - | San Luis | 0:0 | ||||
| 6. Round | 18/05/2021 | Deportes Copiapó | - | Deportes Iquique | 0:2 |  |
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| 7. Round | 23/05/2021 | Deportes Iquique | - | CD Magallanes | 1:1 | ||||
| 8. Round | 30/05/2021 | Santa Cruz | - | Deportes Iquique | 1:3 | ||||
| 9. Round | 06/06/2021 | Deportes Iquique | - | Universidad de Concepción | 5:1 |  |
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| 10. Round | 09/07/2021 | Cobreloa | - | Deportes Iquique | 3:2 | |
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| 11. Round | 15/07/2021 | Unión San Felipe | - | Deportes Iquique | 3:1 | ||||
| 12. Round | 24/07/2021 | Deportes Iquique | - | Santiago Morning | 1:2 | ||||
| 2. Round | 29/07/2021 | Fernández Vial | - | Deportes Iquique | 0:1 | |
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| 13. Round | 01/08/2021 | Rangers | - | Deportes Iquique | 1:0 |
Argentina
Chile