| 3. Round | 04/08/2024 | Club Nacional | - | Sportivo Ameliano | 0:0 | ||||
| 5. Round | 13/08/2024 | Club Nacional | - | Sportivo Luqueño | 1:0 | ||||
| 6. Round | 17/08/2024 | General Caballero DJLM | - | Club Nacional | 0:0 | ||||
| 7. Round | 24/08/2024 | Club Nacional | - | Sol de América | 3:1 | ||||
| 8. Round | 28/08/2024 | Cerro Porteño | - | Club Nacional | 2:1 | ||||
| 9. Round | 02/09/2024 | Club Nacional | - | Tacuary | 1:0 | ||||
| 10. Round | 13/09/2024 | Club Nacional | - | Club Olimpia | 2:0 | ||||
| 11. Round | 17/09/2024 | Guaraní | - | Club Nacional | 0:0 | ||||
| 12. Round | 21/09/2024 | Sportivo Trinidense | - | Club Nacional | 0:2 |  |
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| 13. Round | 29/09/2024 | Club Nacional | - | Libertad | 2:1 | ||||
| 14. Round | 07/10/2024 | Sportivo Ameliano | - | Club Nacional | 1:0 | ||||
| 15. Round | 16/10/2024 | Club Nacional | - | 2 de Mayo | 0:0 | ||||
| 16. Round | 22/10/2024 | Sportivo Luqueño | - | Club Nacional | 2:2 |  |
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| 17. Round | 25/10/2024 | Club Nacional | - | General Caballero DJLM | 1:0 | |
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| 18. Round | 04/11/2024 | Sol de América | - | Club Nacional | 3:2 | ||||
| 19. Round | 10/11/2024 | Club Nacional | - | Cerro Porteño | 2:2 | |
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| 21. Round | 24/11/2024 | Club Olimpia | - | Club Nacional | 1:1 | |
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| 22. Round | 29/11/2024 | Club Nacional | - | Guaraní | 0:0 |
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