| 1. Round | 10/07/2022 | Millonarios | - | Deportivo Pasto | 1:1 |  |
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| 11. Round | 11/09/2022 | Once Caldas | - | Millonarios | 2:1 | ||||
| 13. Round | 22/09/2022 | Atlético Junior | - | Millonarios | 0:1 | ||||
| 14. Round | 24/09/2022 | Millonarios | - | América de Cali | 2:2 | ||||
| 16. Round | 20/10/2022 | Millonarios | - | Deportivo Pereira | 0:1 |  |
Colombia