1. Round | 13/09/2021 | Aris Saloniki | - | OFI Heraklion | 0:0 | ||||
2. Round | 19/09/2021 | OFI Heraklion | - | AEK Athen | 3:3 | ||||
3. Round | 22/09/2021 | OFI Heraklion | - | Asteras Tripolis | 0:0 | ||||
4. Round | 27/09/2021 | PAS Giannina | - | OFI Heraklion | 1:1 | ||||
5. Round | 03/10/2021 | OFI Heraklion | - | PAOK Saloniki | 1:3 | ||||
6. Round | 17/10/2021 | Panetolikos | - | OFI Heraklion | 1:2 | ||||
7. Round | 24/10/2021 | OFI Heraklion | - | Lamia | 0:0 | ||||
8. Round | 31/10/2021 | Panathinaikos | - | OFI Heraklion | 0:0 | ||||
16. Round | 04/01/2022 | Asteras Tripolis | - | OFI Heraklion | 1:0 | ||||
17. Round | 08/01/2022 | OFI Heraklion | - | PAS Giannina | 1:1 | ||||
13. Round | 12/01/2022 | Apollon Smyrnis | - | OFI Heraklion | 0:3 | ||||
18. Round | 15/01/2022 | PAOK Saloniki | - | OFI Heraklion | 3:0 | ||||
19. Round | 22/01/2022 | OFI Heraklion | - | Panetolikos | 2:4 | ||||
21. Round | 02/02/2022 | OFI Heraklion | - | Panathinaikos | 3:2 | ||||
23. Round | 13/02/2022 | OFI Heraklion | - | Volos NFC | 2:1 | ||||
24. Round | 19/02/2022 | Ionikos Nikea | - | OFI Heraklion | 0:0 | ||||
26. Round | 06/03/2022 | OFI Heraklion | - | Apollon Smyrnis | 2:0 |