| 2. Round | 29/01/2016 | Club Rubio Ñu | - | Club Nacional | 2:1 |  |
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| 3. Round | 03/02/2016 | Deportivo Capiatá | - | Club Rubio Ñu | 2:2 | ||||
| 4. Round | 07/02/2016 | Club Rubio Ñu | - | General Díaz | 0:0 | ||||
| 5. Round | 12/02/2016 | Cerro Porteño | - | Club Rubio Ñu | 1:2 | ||||
| 7. Round | 27/02/2016 | General Caballero ZC | - | Club Rubio Ñu | 0:1 |  |
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| 8. Round | 01/03/2016 | Club Rubio Ñu | - | Guaraní | 2:2 | ||||
| 9. Round | 05/03/2016 | River Plate | - | Club Rubio Ñu | 1:4 | ||||
| 10. Round | 13/03/2016 | Club Olimpia | - | Club Rubio Ñu | 4:1 | ||||
| 11. Round | 19/03/2016 | Club Rubio Ñu | - | Sol de América | 0:2 | |
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| 1. Round | 26/03/2016 | Libertad | - | Club Rubio Ñu | 0:1 | ||||
| 13. Round | 07/04/2016 | Club Nacional | - | Club Rubio Ñu | 3:1 | |
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| 14. Round | 10/04/2016 | Club Rubio Ñu | - | Deportivo Capiatá | 1:2 | |
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| 15. Round | 15/04/2016 | General Díaz | - | Club Rubio Ñu | 0:2 |
Paraguay