| 1. Round | 20/01/2007 | CF Monterrey | - | Santos Laguna | 1:0 | ||||
| 2. Round | 29/01/2007 | Santos Laguna | - | Deportivo Guadalajara | 2:3 | ||||
| 3. Round | 04/02/2007 | Club Necaxa | - | Santos Laguna | 1:0 | ||||
| 4. Round | 11/02/2007 | Santos Laguna | - | Gallos Blancos (old) | 0:0 | ||||
| 5. Round | 15/02/2007 | Pumas UNAM | - | Santos Laguna | 2:1 |  |
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| 6. Round | 18/02/2007 | Santos Laguna | - | UAG Tecos | 1:1 | |
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| 7. Round | 25/02/2007 | CF América | - | Santos Laguna | 2:0 | ||||
| 8. Round | 04/03/2007 | Santos Laguna | - | Monarcas Morelia | 2:1 | ||||
| 9. Round | 10/03/2007 | Club San Luis | - | Santos Laguna | 2:3 | ||||
| 10. Round | 15/03/2007 | Santos Laguna | - | UANL Tigres | 0:1 | ||||
| 11. Round | 18/03/2007 | Atlas Guadalajara | - | Santos Laguna | 3:3 | |
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| 12. Round | 25/03/2007 | Santos Laguna | - | Veracruz (old) | 1:0 | ||||
| 13. Round | 31/03/2007 | Jaguares Chiapas | - | Santos Laguna | 1:1 | |
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| 14. Round | 08/04/2007 | Santos Laguna | - | Deportivo Toluca | 2:1 | ||||
| 15. Round | 15/04/2007 | Santos Laguna | - | Atlante | 3:0 | ||||
| 16. Round | 22/04/2007 | CF Pachuca | - | Santos Laguna | 1:0 | |
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| 17. Round | 29/04/2007 | Santos Laguna | - | Cruz Azul | 2:0 |
Mexico