| 1. Round | 05/08/2007 | Santos Laguna | - | Cruz Azul | 2:0 | ||||
| 2. Round | 12/08/2007 | Deportivo Toluca | - | Santos Laguna | 2:3 |  |
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| 3. Round | 19/08/2007 | Santos Laguna | - | Veracruz (old) | 2:0 |  |
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| 4. Round | 26/08/2007 | CF Pachuca | - | Santos Laguna | 0:1 | ||||
| 6. Round | 02/09/2007 | Atlante | - | Santos Laguna | 2:2 | ||||
| 7. Round | 10/09/2007 | Santos Laguna | - | CF América | 4:0 | |
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| 8. Round | 15/09/2007 | CF Monterrey | - | Santos Laguna | 1:1 | ||||
| 9. Round | 23/09/2007 | Santos Laguna | - | Puebla FC | 4:1 | |
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| 10. Round | 29/09/2007 | Jaguares Chiapas | - | Santos Laguna | 2:2 | ||||
| 11. Round | 07/10/2007 | Santos Laguna | - | Pumas UNAM | 3:2 | ||||
| 12. Round | 13/10/2007 | UAG Tecos | - | Santos Laguna | 3:1 | ||||
| 13. Round | 21/10/2007 | Santos Laguna | - | Monarcas Morelia | 3:2 | ||||
| 14. Round | 28/10/2007 | Atlas Guadalajara | - | Santos Laguna | 2:5 | ||||
| 15. Round | 01/11/2007 | Club Necaxa | - | Santos Laguna | 2:3 | ||||
| 16. Round | 04/11/2007 | Santos Laguna | - | UANL Tigres | 0:0 | ||||
| 17. Round | 10/11/2007 | Club San Luis | - | Santos Laguna | 2:2 | |
Mexico