| 1. Round | 27/07/2008 | CF América | - | Santos Laguna | 3:2 | ||||
| 3. Round | 10/08/2008 | Puebla FC | - | Santos Laguna | 0:0 | ||||
| 4. Round | 18/08/2008 | Santos Laguna | - | Indios Juárez | 3:0 | ||||
| 5. Round | 24/08/2008 | Deportivo Guadalajara | - | Santos Laguna | 3:5 | ||||
| 8. Round | 14/09/2008 | Santos Laguna | - | Club Necaxa | 1:1 | ||||
| 9. Round | 20/09/2008 | Cruz Azul | - | Santos Laguna | 1:1 | ||||
| 11. Round | 05/10/2008 | Santos Laguna | - | Monarcas Morelia | 1:0 |
Mexico