| 5. Round | 15/02/2025 | Club Nacional | - | Guaraní | 1:2 | ||||
| 9. Round | 14/03/2025 | Guaraní | - | Atlético Tembetary | 0:0 | ||||
| 14. Round | 16/04/2025 | Guaraní | - | 2 de Mayo | 0:1 | ||||
| 15. Round | 19/04/2025 | Libertad | - | Guaraní | 1:3 | ||||
| 16. Round | 26/04/2025 | Guaraní | - | Club Nacional | 2:1 | ||||
| 18. Round | 10/05/2025 | Guaraní | - | Cerro Porteño | 0:2 | ||||
| 20. Round | 21/05/2025 | Atlético Tembetary | - | Guaraní | 1:2 | ||||
| 21. Round | 24/05/2025 | Guaraní | - | Sportivo Luqueño | 2:1 |
Paraguay