| 1. Round | 16/02/2019 | Montevideo Wanderers | - | River Plate | 1:1 | ||||
| 2. Round | 23/02/2019 | River Plate | - | Racing | 4:1 | ||||
| 4. Round | 10/03/2019 | River Plate | - | Danubio | 1:1 |  |
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| 5. Round | 17/03/2019 | Plaza Colonia | - | River Plate | 1:0 | |
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| 6. Round | 24/03/2019 | River Plate | - | CA Cerro | 2:1 |  |
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| 8. Round | 06/04/2019 | Nacional | - | River Plate | 6:0 | ||||
| 9. Round | 14/04/2019 | River Plate | - | Fénix | 2:2 | ||||
| 10. Round | 20/04/2019 | Progreso | - | River Plate | 4:0 | ||||
| 11. Round | 04/05/2019 | River Plate | - | Peñarol | 0:2 | ||||
| 12. Round | 11/05/2019 | Defensor Sporting | - | River Plate | 1:1 | ||||
| 13. Round | 18/05/2019 | River Plate | - | Rampla Juniors | 2:1 | ||||
| 14. Round | 25/05/2019 | Juventud de Las Piedras | - | River Plate | 4:1 | ||||
| 15. Round | 02/06/2019 | River Plate | - | Liverpool | 0:0 |
Uruguay