| 2. Round | 24/05/2021 | River Plate | - | Liverpool | 3:2 | ||||
| 4. Round | 06/06/2021 | Cerro Largo | - | River Plate | 2:4 | ||||
| 9. Round | 03/07/2021 | River Plate | - | Boston River | 1:1 | ||||
| 10. Round | 10/07/2021 | Montevideo Wanderers | - | River Plate | 1:2 | ||||
| 13. Round | 07/08/2021 | River Plate | - | Montevideo City Torque | 3:3 | ||||
| 14. Round | 15/08/2021 | Villa Española | - | River Plate | 1:1 |
Uruguay