| 5. Round | 09/10/2021 | Progreso | - | River Plate | 1:0 |  |
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| 7. Round | 20/10/2021 | Plaza Colonia | - | River Plate | 0:0 | ||||
| 9. Round | 30/10/2021 | Boston River | - | River Plate | 1:2 | ||||
| 10. Round | 03/11/2021 | River Plate | - | Montevideo Wanderers | 0:1 | ||||
| 12. Round | 14/11/2021 | River Plate | - | Peñarol | 1:1 | ||||
| 13. Round | 22/11/2021 | Montevideo City Torque | - | River Plate | 1:1 | ||||
| 14. Round | 30/11/2021 | River Plate | - | Villa Española | 4:2 | ||||
| 15. Round | 04/12/2021 | Nacional | - | River Plate | 4:2 |
Uruguay