| 1. Round | 09/01/2021 | UANL Tigres [U20] | - | Club León [U20] | 6:0 | ||||
| 7. Round | 21/02/2021 | Pumas UNAM [U20] | - | Club León [U20] | 1:4 |  |
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| 3. Round | 10/03/2021 | CF Monterrey [U20] | - | Club León [U20] | 0:0 |  |
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| 14. Round | 10/04/2021 | Atlas Guadalajara [U20] | - | Club León [U20] | 2:1 | ||||
| 15. Round | 19/04/2021 | Club León [U20] | - | FC Juárez [U20] | 1:2 | ||||
| 16. Round | 23/04/2021 | Mazatlán FC [U20] | - | Club León [U20] | 1:3 | ||||
| 17. Round | 01/05/2021 | Club León [U20] | - | Gallos Blancos [U20] | 3:0 |
Mexico