| 1. Round | 05/02/2022 | Resistencia SC | - | Tacuary | 1:0 | ||||
| 7. Round | 19/03/2022 | Resistencia SC | - | Cerro Porteño | 0:3 | ||||
| 8. Round | 02/04/2022 | Resistencia SC | - | Club Olimpia | 2:1 | ||||
| 9. Round | 08/04/2022 | 12 de Octubre de Itauguá | - | Resistencia SC | 1:1 | ||||
| 10. Round | 18/04/2022 | Resistencia SC | - | General Caballero DJLM | 2:1 | ||||
| 11. Round | 21/04/2022 | Libertad | - | Resistencia SC | 2:2 | ||||
| 12. Round | 25/04/2022 | Tacuary | - | Resistencia SC | 3:1 | ||||
| 13. Round | 29/04/2022 | Resistencia SC | - | Sportivo Ameliano | 3:0 |  |
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| 14. Round | 06/05/2022 | Club Nacional | - | Resistencia SC | 1:2 | ||||
| 21. Round | 25/06/2022 | General Caballero DJLM | - | Resistencia SC | 2:1 |
Paraguay