| 1. Round | 22/01/2020 | Blooming | - | Real Santa Cruz | 1:1 |  |
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| 2. Round | 26/01/2020 | Real Santa Cruz | - | The Strongest | 3:2 | |
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| 4. Round | 02/02/2020 | Real Potosí | - | Real Santa Cruz | 2:1 | ||||
| 3. Round | 05/02/2020 | Real Santa Cruz | - | Club San José | 1:1 | |
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| 6. Round | 14/02/2020 | Jorge Wilstermann | - | Real Santa Cruz | 0:0 | |
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| 7. Round | 16/02/2020 | Real Santa Cruz | - | Oriente Petrolero | 1:5 | |
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| 9. Round | 27/02/2020 | Real Santa Cruz | - | Bolívar | 2:4 | |
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| 10. Round | 03/03/2020 | Royal Pari | - | Real Santa Cruz | 0:2 | ||||
| 11. Round | 06/03/2020 | Real Santa Cruz | - | Nacional Potosí | 2:1 | ||||
| 12. Round | 15/03/2020 | CD Guabirá | - | Real Santa Cruz | 1:0 | |
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| 15. Round | 02/12/2020 | The Strongest | - | Real Santa Cruz | 4:2 | ||||
| 16. Round | 07/12/2020 | Club San José | - | Real Santa Cruz | 4:1 | ||||
| 17. Round | 09/12/2020 | Real Santa Cruz | - | Real Potosí | 3:1 | ||||
| 18. Round | 12/12/2020 | Real Santa Cruz | - | Always Ready | 0:3 | ||||
| 24. Round | 27/12/2020 | Nacional Potosí | - | Real Santa Cruz | 1:0 | ||||
| 25. Round | 29/12/2020 | Real Santa Cruz | - | CD Guabirá | 4:4 | |
Bolivia