| 4. Round | 26/01/2019 | CF Monterrey [U20] | - | CF América [U20] | 1:1 |  |
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| 5. Round | 02/02/2019 | CF América [U20] | - | Gallos Blancos [U20] | 0:1 | ||||
| 6. Round | 09/02/2019 | CF América [U20] | - | Club León [U20] | 1:1 | ||||
| 7. Round | 16/02/2019 | Pumas UNAM [U20] | - | CF América [U20] | 1:1 | ||||
| 8. Round | 23/02/2019 | CF América [U20] | - | Lobos BUAP [U20] | 0:1 | ||||
| 9. Round | 01/03/2019 | Monarcas Morelia [U20] | - | CF América [U20] | 2:0 | |
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| 1. Round | 05/03/2019 | CF América [U20] | - | Club Necaxa [U20] | 0:0 | ||||
| 10. Round | 09/03/2019 | CF América [U20] | - | Puebla FC [U20] | 3:1 | ||||
| 11. Round | 16/03/2019 | Deportivo Guadalajara [U20] | - | CF América [U20] | 2:0 | ||||
| 12. Round | 30/03/2019 | CF América [U20] | - | UANL Tigres [U20] | 1:0 | ||||
| 13. Round | 06/04/2019 | Club Tijuana [U20] | - | CF América [U20] | 0:0 | ||||
| 14. Round | 14/04/2019 | CF América [U20] | - | Cruz Azul [U20] | 2:0 | ||||
| 15. Round | 21/04/2019 | Deportivo Toluca [U20] | - | CF América [U20] | 1:1 | ||||
| 16. Round | 27/04/2019 | CF América [U20] | - | Santos Laguna [U20] | 3:3 | |
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| 17. Round | 03/05/2019 | CD Veracruz [U20] | - | CF América [U20] | 0:1 | |
Mexico