1. Round | 09/01/2022 | Santos Laguna [] | - | CF Monterrey [] | 2:1 | ||||
3. Round | 22/01/2022 | UANL Tigres [] | - | Santos Laguna [] | 2:1 | ||||
5. Round | 04/02/2022 | Atlético San Luis [] | - | Santos Laguna [] | 0:2 | ||||
6. Round | 12/02/2022 | Santos Laguna [] | - | Atlas Guadalajara [] | 4:3 | ||||
7. Round | 18/02/2022 | Club León [] | - | Santos Laguna [] | 2:2 | ||||
13. Round | 02/04/2022 | CF Monterrey [] | - | Santos Laguna [] | 2:0 | ||||
16. Round | 23/04/2022 | Santos Laguna [] | - | UANL Tigres [] | 5:0 |