| 1. Round | 07/01/2023 | Club Necaxa | - | Atlético San Luis | 2:3 |  |
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| 2. Round | 14/01/2023 | Atlético San Luis | - | Deportivo Guadalajara | 0:0 |  |
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| 4. Round | 29/01/2023 | UANL Tigres | - | Atlético San Luis | 0:0 | ||||
| 5. Round | 03/02/2023 | Atlético San Luis | - | Puebla FC | 2:0 | ||||
| 6. Round | 11/02/2023 | Club Tijuana | - | Atlético San Luis | 1:0 | ||||
| 7. Round | 15/02/2023 | Atlético San Luis | - | CF América | 1:3 | ||||
| 8. Round | 18/02/2023 | Atlético San Luis | - | Santos Laguna | 1:1 | ||||
| 10. Round | 04/03/2023 | Club León | - | Atlético San Luis | 2:0 | ||||
| 11. Round | 11/03/2023 | Atlético San Luis | - | Gallos Blancos | 2:0 |  |
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| 12. Round | 18/03/2023 | Cruz Azul | - | Atlético San Luis | 1:0 | ||||
| 13. Round | 03/04/2023 | Atlético San Luis | - | Mazatlán FC | 2:1 | ||||
| 14. Round | 09/04/2023 | Pumas UNAM | - | Atlético San Luis | 3:1 | ||||
| 15. Round | 14/04/2023 | Atlético San Luis | - | FC Juárez | 2:0 | |
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| 16. Round | 23/04/2023 | CF Pachuca | - | Atlético San Luis | 2:1 | |
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| 17. Round | 30/04/2023 | Atlético San Luis | - | Atlas Guadalajara | 0:0 |
Uruguay
Spain