| 2. Round | 15/01/2022 | CF Monterrey [U16] | - | Deportivo Guadalajara [U16] | 2:2 | ||||
| 3. Round | 22/01/2022 | Deportivo Guadalajara [U16] | - | Club León [U16] | 2:1 | ||||
| 4. Round | 29/01/2022 | Santos Laguna [U16] | - | Deportivo Guadalajara [U16] | 0:1 | ||||
| 5. Round | 05/02/2022 | Club Tijuana [U16] | - | Deportivo Guadalajara [U16] | 0:1 | ||||
| 7. Round | 19/02/2022 | Deportivo Guadalajara [U16] | - | Mazatlán FC [U16] | 7:1 | ||||
| 10. Round | 12/03/2022 | Atlético San Luis [U16] | - | Deportivo Guadalajara [U16] | 0:1 | ||||
| 11. Round | 19/03/2022 | Deportivo Guadalajara [U16] | - | Club Tijuana [U16] | 2:0 |  |
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| 12. Round | 26/03/2022 | Club León [U16] | - | Deportivo Guadalajara [U16] | 0:3 | ||||
| 15. Round | 30/03/2022 | Deportivo Guadalajara [U16] | - | CF Monterrey [U16] | 5:1 | ||||
| 16. Round | 23/04/2022 | Atlas Guadalajara [U16] | - | Deportivo Guadalajara [U16] | 2:2 | ||||
| 17. Round | 30/04/2022 | Deportivo Guadalajara [U16] | - | Santos Laguna [U16] | 3:0 | ||||
| 18. Round | 07/05/2022 | Deportivo Guadalajara [U16] | - | UANL Tigres [U16] | 4:3 |
Mexico