| 1. Round | 08/01/2022 | Pumas UNAM [] | - | Cruz Azul [] | 2:1 |  |
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| 2. Round | 15/01/2022 | Cruz Azul [] | - | CF Pachuca [] | 1:4 | ||||
| 3. Round | 22/01/2022 | Club Necaxa [] | - | Cruz Azul [] | 4:1 | |
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| 4. Round | 29/01/2022 | Cruz Azul [] | - | Gallos Blancos [] | 0:1 | ||||
| 5. Round | 05/02/2022 | Deportivo Toluca [] | - | Cruz Azul [] | 1:1 | ||||
| 7. Round | 19/02/2022 | FC Juárez [] | - | Cruz Azul [] | 3:1 | |
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| 8. Round | 26/02/2022 | Cruz Azul [] | - | Puebla FC [] | 4:1 | |
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| 9. Round | 05/03/2022 | Cruz Azul [] | - | CF América [] | 3:1 | |
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| 10. Round | 12/03/2022 | CF Pachuca [] | - | Cruz Azul [] | 4:2 | ||||
| 11. Round | 19/03/2022 | Gallos Blancos [] | - | Cruz Azul [] | 4:0 | ||||
| 15. Round | 23/03/2022 | Cruz Azul [] | - | Pumas UNAM [] | 1:4 | ||||
| 12. Round | 26/03/2022 | Cruz Azul [] | - | FC Juárez [] | 0:2 | |
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| 13. Round | 02/04/2022 | Cruz Azul [] | - | Deportivo Toluca [] | 1:1 | ||||
| 18. Round | 07/05/2022 | Cruz Azul [] | - | Club Necaxa [] | 1:3 |
Mexico