| 1. Round | 26/07/2020 | Pumas UNAM | - | Gallos Blancos | 3:2 | ||||
| 2. Round | 04/08/2020 | Atlas Guadalajara | - | Pumas UNAM | 1:2 | ||||
| 9. Round | 10/09/2020 | Santos Laguna | - | Pumas UNAM | 1:2 | ||||
| 10. Round | 13/09/2020 | Pumas UNAM | - | Atlético San Luis | 3:0 |  |
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| 11. Round | 22/09/2020 | Club León | - | Pumas UNAM | 2:0 | ||||
| 12. Round | 27/09/2020 | Pumas UNAM | - | Club Necaxa | 1:1 | ||||
| 13. Round | 04/10/2020 | CF América | - | Pumas UNAM | 2:2 | |
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| 14. Round | 18/10/2020 | Pumas UNAM | - | Deportivo Toluca | 1:0 | ||||
| 15. Round | 27/10/2020 | CF Pachuca | - | Pumas UNAM | 1:1 | |
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| 16. Round | 01/11/2020 | Pumas UNAM | - | Deportivo Guadalajara | 2:2 |  |
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| 17. Round | 08/11/2020 | Cruz Azul | - | Pumas UNAM | 1:2 |
Mexico