| 1. Round | 09/01/2021 | UANL Tigres [U20] | - | Club León [U20] | 6:0 | ||||
| 2. Round | 18/01/2021 | Club León [U20] | - | CF Pachuca [U20] | 0:3 | ||||
| 5. Round | 08/02/2021 | Club León [U20] | - | Deportivo Guadalajara [U20] | 3:0 | ||||
| 6. Round | 12/02/2021 | Club Tijuana [U20] | - | Club León [U20] | 1:1 | ||||
| 7. Round | 21/02/2021 | Pumas UNAM [U20] | - | Club León [U20] | 1:4 |  |
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| 8. Round | 27/02/2021 | Club León [U20] | - | Cruz Azul [U20] | 1:2 | ||||
| 9. Round | 02/03/2021 | Club León [U20] | - | Puebla FC [U20] | 2:1 | ||||
| 10. Round | 06/03/2021 | CF América [U20] | - | Club León [U20] | 0:1 | ||||
| 3. Round | 10/03/2021 | CF Monterrey [U20] | - | Club León [U20] | 0:0 | ||||
| 11. Round | 15/03/2021 | Club León [U20] | - | Club Necaxa [U20] | 2:1 | ||||
| 12. Round | 21/03/2021 | Santos Laguna [U20] | - | Club León [U20] | 3:0 | ||||
| 4. Round | 26/03/2021 | Club León [U20] | - | Atlético San Luis [U20] | 4:2 |  |
Mexico