| 1. Round | 03/07/2022 | Atlético San Luis [U20] | - | Club León [U20] | 1:3 | ||||
| 2. Round | 10/07/2022 | Club León [U20] | - | Pumas UNAM [U20] | 3:2 | ||||
| 3. Round | 15/07/2022 | Puebla FC [U20] | - | Club León [U20] | 3:1 |  |
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| 4. Round | 20/07/2022 | Deportivo Guadalajara [U20] | - | Club León [U20] | 1:3 | ||||
| 5. Round | 26/07/2022 | Club León [U20] | - | Deportivo Toluca [U20] | 0:0 | ||||
| 6. Round | 31/07/2022 | Club León [U20] | - | CF América [U20] | 1:0 | ||||
| 7. Round | 06/08/2022 | CF Monterrey [U20] | - | Club León [U20] | 2:0 | ||||
| 9. Round | 18/08/2022 | Santos Laguna [U20] | - | Club León [U20] | 2:3 | ||||
| 11. Round | 28/08/2022 | Club León [U20] | - | Atlas Guadalajara [U20] | 0:1 | |
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| 12. Round | 02/09/2022 | Club Necaxa [U20] | - | Club León [U20] | 2:2 | ||||
| 13. Round | 06/09/2022 | Club León [U20] | - | FC Juárez [U20] | 3:1 | |
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| 14. Round | 10/09/2022 | UANL Tigres [U20] | - | Club León [U20] | 3:2 | ||||
| 16. Round | 15/09/2022 | Cruz Azul [U20] | - | Club León [U20] | 1:1 | ||||
| 15. Round | 18/09/2022 | Club León [U20] | - | Gallos Blancos [U20] | 3:2 | ||||
| 8. Round | 27/09/2022 | Club León [U20] | - | Mazatlán FC [U20] | 4:1 |  |
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| 17. Round | 02/10/2022 | Club León [U20] | - | Club Tijuana [U20] | 1:0 | |
Mexico