| 3. Round | 28/09/2020 | AE Lárissa | - | Panathinaikos | 1:1 |  |
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| 4. Round | 04/10/2020 | Panathinaikos | - | Aris Saloniki | 0:1 | ||||
| 9. Round | 21/11/2020 | Olympiakos Piraeus | - | Panathinaikos | 1:0 | |
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| 11. Round | 06/12/2020 | AEK Athen | - | Panathinaikos | 1:2 | ||||
| 13. Round | 20/12/2020 | PAOK Saloniki | - | Panathinaikos | 2:1 | ||||
| 14. Round | 03/01/2021 | Panathinaikos | - | Asteras Tripolis | 0:0 | ||||
| 15. Round | 06/01/2021 | Apollon Smyrnis | - | Panathinaikos | 0:1 | ||||
| 16. Round | 10/01/2021 | Panathinaikos | - | AE Lárissa | 2:0 | ||||
| 17. Round | 17/01/2021 | Aris Saloniki | - | Panathinaikos | 0:1 | ||||
| 18. Round | 23/01/2021 | Panathinaikos | - | OFI Heraklion | 2:0 | ||||
| 19. Round | 27/01/2021 | Volos NFC | - | Panathinaikos | 0:2 |  |
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| 22. Round | 14/02/2021 | Panathinaikos | - | Olympiakos Piraeus | 2:1 | ||||
| 23. Round | 22/02/2021 | Panetolikos | - | Panathinaikos | 1:0 | ||||
| 24. Round | 28/02/2021 | Panathinaikos | - | AEK Athen | 1:1 | ||||
| 25. Round | 06/03/2021 | PAS Giannina | - | Panathinaikos | 1:0 | ||||
| 26. Round | 14/03/2021 | Panathinaikos | - | PAOK Saloniki | 2:1 |
Spain