| 1. Round | 11/07/2022 | Santos Laguna [Women] | - | Gallos Blancos [Women] | 4:3 | ||||
| 3. Round | 26/07/2022 | Santos Laguna [Women] | - | CF Pachuca [Women] | 3:2 | ||||
| 4. Round | 29/07/2022 | Deportivo Toluca [Women] | - | Santos Laguna [Women] | 2:0 | ||||
| 5. Round | 02/08/2022 | Santos Laguna [Women] | - | Club León [Women] | 1:2 | ||||
| 6. Round | 06/08/2022 | Cruz Azul [Women] | - | Santos Laguna [Women] | 0:1 |  |
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| 7. Round | 16/08/2022 | Santos Laguna [Women] | - | Pumas UNAM [Women] | 1:2 | ||||
| 8. Round | 19/08/2022 | Deportivo Guadalajara [Women] | - | Santos Laguna [Women] | 3:1 | ||||
| 11. Round | 13/09/2022 | Santos Laguna [Women] | - | Club Tijuana [Women] | 1:2 | ||||
| 12. Round | 20/09/2022 | FC Juárez [Women] | - | Santos Laguna [Women] | 4:1 | ||||
| 13. Round | 22/09/2022 | Club Necaxa [Women] | - | Santos Laguna [Women] | 1:1 | |
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| 14. Round | 27/09/2022 | Santos Laguna [Women] | - | Mazatlán FC [Women] | 3:2 | ||||
| 16. Round | 16/10/2022 | Atlético San Luis [Women] | - | Santos Laguna [Women] | 0:2 |
Mexico