| Group D | 14/04/2022 | Independiente del Valle | - | Deportes Tolima | 2:2 | ||||
| Group D | 27/04/2022 | América - MG | - | Deportes Tolima | 2:3 |  |
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| Group D | 05/05/2022 | Deportes Tolima | - | Independiente del Valle | 1:0 |  |
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| Group D | 19/05/2022 | Deportes Tolima | - | América - MG | 2:2 | ||||
| Group D | 26/05/2022 | Atlético Mineiro | - | Deportes Tolima | 1:2 | ||||
| Round of 16 | 30/06/2022 | Deportes Tolima | - | Flamengo RJ | 0:1 | ||||
| Round of 16 | 07/07/2022 | Flamengo RJ | - | Deportes Tolima | 7:1 | |
Colombia