| 2. Round | 27/08/2010 | Independiente | - | Argentinos Juniors | 1:0 | ||||
| 2. Round | 09/09/2010 | Argentinos Juniors | - | Independiente | 1:1 |  |
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| Round of 16 | 29/09/2010 | Defensor Sporting | - | Independiente | 1:0 | |
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| Round of 16 | 19/10/2010 | Independiente | - | Defensor Sporting | 4:2 | ||||
| Quarter-finals | 04/11/2010 | Deportes Tolima | - | Independiente | 2:2 |  |
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| Quarter-finals | 12/11/2010 | Independiente | - | Deportes Tolima | 0:0 | |
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| Semi-finals | 19/11/2010 | LDU Quito | - | Independiente | 3:2 | ||||
| Semi-finals | 26/11/2010 | Independiente | - | LDU Quito | 2:1 | ||||
| Final | 02/12/2010 | Goiás - GO | - | Independiente | 2:0 | |
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| Final | 09/12/2010 | Independiente | - | Goiás - GO | 5:3 pso | |
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Argentina