| 1. Round | 21/09/1958 | Genoa CFC | - | SSC Napoli | 3:3 |  |
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| 2. Round | 28/09/1958 | Bologna FC | - | Genoa CFC | 2:1 | ||||
| 22. Round | 08/03/1959 | AS Bari | - | Genoa CFC | 1:2 | ||||
| 23. Round | 15/03/1959 | Genoa CFC | - | US Alessandria 1912 | 1:1 | ||||
| 24. Round | 22/03/1959 | US Triestina | - | Genoa CFC | 2:1 | ||||
| 25. Round | 29/03/1959 | Genoa CFC | - | Sampdoria | 0:0 | ||||
| 26. Round | 05/04/1959 | Udinese Calcio | - | Genoa CFC | 4:0 | ||||
| 27. Round | 12/04/1959 | Genoa CFC | - | Calcio Padova | 2:1 | ||||
| 30. Round | 17/05/1959 | Genoa CFC | - | ACF Fiorentina | 0:0 | ||||
| 31. Round | 24/05/1959 | AC Milan | - | Genoa CFC | 4:0 | ||||
| 32. Round | 28/05/1959 | Genoa CFC | - | Lazio Roma | 0:0 | ||||
| 33. Round | 02/06/1959 | SPAL Ferrara | - | Genoa CFC | 1:5 | |
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| 34. Round | 06/06/1959 | Juventus | - | Genoa CFC | 4:3 | |
Uruguay