| 1. Round | 20/09/1959 | AS Roma | - | Genoa CFC | 1:0 | ||||
| 2. Round | 27/09/1959 | Genoa CFC | - | Bologna FC | 0:2 | ||||
| 3. Round | 04/10/1959 | SSC Napoli | - | Genoa CFC | 0:2 dec. | ||||
| 4. Round | 11/10/1959 | AS Bari | - | Genoa CFC | 1:0 | ||||
| 5. Round | 18/10/1959 | Genoa CFC | - | AC Milan | 0:2 | ||||
| 8. Round | 15/11/1959 | Genoa CFC | - | Sampdoria | 1:2 |  |
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| 12. Round | 20/12/1959 | Genoa CFC | - | US Alessandria 1912 | 1:0 | |
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| 13. Round | 27/12/1959 | Inter | - | Genoa CFC | 2:0 | ||||
| 14. Round | 10/01/1960 | Genoa CFC | - | SPAL Ferrara | 0:1 | ||||
| 16. Round | 24/01/1960 | US Palermo | - | Genoa CFC | 1:1 | ||||
| 17. Round | 31/01/1960 | Genoa CFC | - | ACF Fiorentina | 0:0 | ||||
| 15. Round | 03/02/1960 | Lazio Roma | - | Genoa CFC | 0:0 | ||||
| 20. Round | 21/02/1960 | Genoa CFC | - | SSC Napoli | 0:0 | ||||
| 23. Round | 20/03/1960 | AC Lanerossi Vicenza | - | Genoa CFC | 1:0 | ||||
| 24. Round | 27/03/1960 | Genoa CFC | - | Udinese Calcio | 0:0 | ||||
| 25. Round | 03/04/1960 | Sampdoria | - | Genoa CFC | 3:0 | ||||
| 26. Round | 10/04/1960 | Genoa CFC | - | Juventus | 2:6 | |
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| 31. Round | 15/05/1960 | SPAL Ferrara | - | Genoa CFC | 0:0 | ||||
| 32. Round | 22/05/1960 | Genoa CFC | - | Lazio Roma | 2:4 | ||||
| 33. Round | 29/05/1960 | Genoa CFC | - | US Palermo | 1:1 |
Uruguay