| 2. Round | 15/01/2022 | Atlas Guadalajara [U16] | - | Club Tijuana [U16] | 3:0 | ||||
| 4. Round | 29/01/2022 | UANL Tigres [U16] | - | Club Tijuana [U16] | 3:0 | ||||
| 6. Round | 12/02/2022 | Mazatlán FC [U16] | - | Club Tijuana [U16] | 1:2 |  |
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| 7. Round | 19/02/2022 | Club Tijuana [U16] | - | CF Monterrey [U16] | 1:0 |  |
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| 9. Round | 05/03/2022 | Santos Laguna [U16] | - | Club Tijuana [U16] | 2:0 | ||||
| 11. Round | 19/03/2022 | Deportivo Guadalajara [U16] | - | Club Tijuana [U16] | 2:0 | |
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| 12. Round | 26/03/2022 | Club Tijuana [U16] | - | UANL Tigres [U16] | 2:1 | |
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| 14. Round | 05/04/2022 | Atlético San Luis [U16] | - | Club Tijuana [U16] | 3:1 | ||||
| 16. Round | 23/04/2022 | Club León [U16] | - | Club Tijuana [U16] | 1:0 | ||||
| 17. Round | 30/04/2022 | Club Tijuana [U16] | - | Mazatlán FC [U16] | 1:2 | |
Mexico