| 1. Round | 06/01/2022 | Alebrijes de Oaxaca | - | Cancún FC | 2:0 | ||||
| 2. Round | 12/01/2022 | TM Fútbol Club | - | Alebrijes de Oaxaca | 1:1 | ||||
| 3. Round | 20/01/2022 | Alebrijes de Oaxaca | - | Leones Negros | 1:1 | ||||
| 4. Round | 26/01/2022 | CF Monterrey II | - | Alebrijes de Oaxaca | 2:0 | ||||
| 5. Round | 29/01/2022 | Alebrijes de Oaxaca | - | Atlético Morelia | 1:1 |  |
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| 6. Round | 01/02/2022 | Tepatitlán | - | Alebrijes de Oaxaca | 1:2 |  |
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| 7. Round | 09/02/2022 | Alebrijes de Oaxaca | - | Venados FC | 1:0 | ||||
| 8. Round | 17/02/2022 | Cimarrones de Sonora | - | Alebrijes de Oaxaca | 0:1 |  |
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| 16. Round | 05/04/2022 | Alebrijes de Oaxaca | - | Pumas Tabasco | 0:0 | ||||
| 17. Round | 13/04/2022 | Correcaminos UAT | - | Alebrijes de Oaxaca | 0:1 |
Mexico