| 19. Round | 19/02/2021 | Club Irapuato | - | Cafessa Jalisco | 0:0 | ||||
| 20. Round | 28/02/2021 | Cafessa Jalisco | - | Club de Ciervos | 3:0 |  |
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| 21. Round | 05/03/2021 | Cañoneros Marina | - | Cafessa Jalisco | 2:3 | ||||
| 22. Round | 14/03/2021 | Cafessa Jalisco | - | Cruz Azul Hidalgo | 1:3 | |
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| 23. Round | 21/03/2021 | CD Cuautla | - | Cafessa Jalisco | 0:2 | |
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| 24. Round | 01/04/2021 | Cafessa Jalisco | - | Deportivo Dongu | 1:0 | ||||
| 25. Round | 03/04/2021 | Aguacateros CDU | - | Cafessa Jalisco | 1:0 | ||||
| 26. Round | 10/04/2021 | Cafessa Jalisco | - | Pioneros de Cancún | 0:0 |
Mexico
France