1. Round | 06/02/2022 | Cerro Porteño | - | Sportivo Ameliano | 3:2 | ||||
2. Round | 13/02/2022 | Club Nacional | - | Cerro Porteño | 2:3 | ||||
13. Round | 01/05/2022 | Cerro Porteño | - | Club Nacional | 1:0 | ||||
14. Round | 09/05/2022 | Guaraní | - | Cerro Porteño | 1:2 | ||||
15. Round | 12/05/2022 | Cerro Porteño | - | Guaireña FC | 0:0 | ||||
17. Round | 22/05/2022 | Club Olimpia | - | Cerro Porteño | 0:4 | ||||
22. Round | 02/07/2022 | Cerro Porteño | - | Tacuary | 1:0 |