| 1. Round | 23/07/2017 | FK Senica | - | AS Trenčín | 1:2 | ||||
| 2. Round | 30/07/2017 | MFK Ružomberok | - | FK Senica | 4:0 | ||||
| 3. Round | 04/08/2017 | FK Senica | - | Slovan Bratislava | 1:1 |  |
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| 4. Round | 12/08/2017 | MŠK Žilina | - | FK Senica | 7:1 | |
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| 5. Round | 19/08/2017 | FK Senica | - | FC Nitra | 0:1 | |
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| 6. Round | 26/08/2017 | 1. FC Tatran Prešov | - | FK Senica | 2:2 | ||||
| 7. Round | 09/09/2017 | FK Senica | - | Zlaté Moravce | 0:1 | ||||
| 8. Round | 16/09/2017 | MFK Zemplín Michalovce | - | FK Senica | 2:1 | ||||
| 9. Round | 20/09/2017 | FC DAC 1904 | - | FK Senica | 1:0 | ||||
| 10. Round | 23/09/2017 | FK Senica | - | Spartak Trnava | 1:3 |  |
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| 11. Round | 30/09/2017 | FK Železiarne Podbrezová | - | FK Senica | 1:0 | ||||
| 13. Round | 21/10/2017 | FK Senica | - | MFK Ružomberok | 0:3 | ||||
| 14. Round | 28/10/2017 | Slovan Bratislava | - | FK Senica | 2:2 | ||||
| 15. Round | 05/11/2017 | FK Senica | - | MŠK Žilina | 4:1 | |
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| 17. Round | 25/11/2017 | FK Senica | - | 1. FC Tatran Prešov | 1:0 | |
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| 18. Round | 02/12/2017 | Zlaté Moravce | - | FK Senica | 3:0 | ||||
| 19. Round | 09/12/2017 | FK Senica | - | MFK Zemplín Michalovce | 1:1 | |
Kazakhstan