| 2. Round | 31/07/2021 | Slovan Bratislava | - | AS Trenčín | 2:0 | ||||
| 9. Round | 25/09/2021 | FK Senica | - | Slovan Bratislava | 0:3 | ||||
| 10. Round | 03/10/2021 | Slovan Bratislava | - | FK Pohronie | 5:1 | ||||
| 11. Round | 17/10/2021 | Spartak Trnava | - | Slovan Bratislava | 0:3 dec. | ||||
| 12. Round | 24/10/2021 | Slovan Bratislava | - | Tatran Liptovský Mikuláš | 4:0 | ||||
| 13. Round | 31/10/2021 | AS Trenčín | - | Slovan Bratislava | 2:3 | ||||
| 15. Round | 21/11/2021 | MFK Zemplín Michalovce | - | Slovan Bratislava | 1:2 | ||||
| 16. Round | 29/11/2021 | Slovan Bratislava | - | ŠKF Sereď | 2:0 | ||||
| 17. Round | 03/12/2021 | Zlaté Moravce | - | Slovan Bratislava | 1:2 | ||||
| 18. Round | 12/12/2021 | Slovan Bratislava | - | FC DAC 1904 | 0:0 |
Kazakhstan