| 1. Round | 09/07/2022 | Pumas UNAM [Women] | - | Mazatlán FC [Women] | 3:0 | ||||
| 2. Round | 17/07/2022 | Mazatlán FC [Women] | - | FC Juárez [Women] | 1:2 | ||||
| 3. Round | 25/07/2022 | Club Necaxa [Women] | - | Mazatlán FC [Women] | 1:1 | ||||
| 4. Round | 30/07/2022 | Mazatlán FC [Women] | - | CF América [Women] | 0:3 | ||||
| 5. Round | 02/08/2022 | Mazatlán FC [Women] | - | Puebla FC [Women] | 1:0 | ||||
| 6. Round | 05/08/2022 | Gallos Blancos [Women] | - | Mazatlán FC [Women] | 2:2 | ||||
| 7. Round | 16/08/2022 | Mazatlán FC [Women] | - | UANL Tigres [Women] | 0:8 | ||||
| 8. Round | 23/08/2022 | Mazatlán FC [Women] | - | CF Monterrey [Women] | 0:1 | ||||
| 9. Round | 25/08/2022 | Club León [Women] | - | Mazatlán FC [Women] | 3:1 | ||||
| 10. Round | 28/08/2022 | Deportivo Guadalajara [Women] | - | Mazatlán FC [Women] | 7:0 | ||||
| 11. Round | 13/09/2022 | Mazatlán FC [Women] | - | Deportivo Toluca [Women] | 3:1 | ||||
| 12. Round | 17/09/2022 | Cruz Azul [Women] | - | Mazatlán FC [Women] | 1:0 | ||||
| 16. Round | 15/10/2022 | Atlas Guadalajara [Women] | - | Mazatlán FC [Women] | 5:0 | ||||
| 17. Round | 25/10/2022 | Mazatlán FC [Women] | - | CF Pachuca [Women] | 3:1 |
Mexico