| 6. Round | 05/02/2019 | Santos Laguna [Women] | - | Club León [Women] | 0:1 | ||||
| 7. Round | 09/02/2019 | Atlas Guadalajara [Women] | - | Santos Laguna [Women] | 3:4 | ||||
| 9. Round | 22/02/2019 | Santos Laguna [Women] | - | CF Monterrey [Women] | 0:1 | ||||
| 10. Round | 26/02/2019 | Santos Laguna [Women] | - | Club Necaxa [Women] | 3:0 | ||||
| 11. Round | 03/03/2019 | Monarcas Morelia [Women] | - | Santos Laguna [Women] | 2:2 |  |
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| 12. Round | 12/03/2019 | Santos Laguna [Women] | - | Deportivo Guadalajara [Women] | 3:1 | ||||
| 15. Round | 02/04/2019 | Club León [Women] | - | Santos Laguna [Women] | 1:0 | ||||
| 16. Round | 09/04/2019 | Santos Laguna [Women] | - | Atlas Guadalajara [Women] | 0:2 | ||||
| 18. Round | 20/04/2019 | CF Monterrey [Women] | - | Santos Laguna [Women] | 3:2 |
Mexico