| 4. Round | 11/07/2021 | Atlanta United II | - | Sporting Kansas City 2 | 0:1 | ||||
| 5. Round | 01/08/2021 | Sporting Kansas City 2 | - | Memphis 901 | 1:2 | ||||
| 5. Round | 22/08/2021 | Sporting Kansas City 2 | - | Indy Eleven | 1:1 | ||||
| 5. Round | 29/08/2021 | Sporting Kansas City 2 | - | Memphis 901 | 0:0 | ||||
| 6. Round | 25/09/2021 | Sporting Kansas City 2 | - | FC Tulsa | 1:1 | ||||
| 7. Round | 02/10/2021 | Sporting Kansas City 2 | - | Birmingham Legion | 0:1 | ||||
| 7. Round | 07/10/2021 | Memphis 901 | - | Sporting Kansas City 2 | 3:1 |  |
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| 7. Round | 10/10/2021 | Louisville City FC | - | Sporting Kansas City 2 | 4:3 |
USA