| 3. Round | 15/08/2021 | Werder Bremen | - | SC Paderborn 07 | 1:4 | ||||
| 5. Round | 29/08/2021 | Dynamo Dresden | - | SC Paderborn 07 | 0:3 | ||||
| 6. Round | 12/09/2021 | SC Paderborn 07 | - | FC Schalke 04 | 0:1 | ||||
| 12. Round | 31/10/2021 | Karlsruher SC | - | SC Paderborn 07 | 2:4 | ||||
| 15. Round | 28/11/2021 | SC Paderborn 07 | - | Hansa Rostock | 1:1 | ||||
| 17. Round | 11/12/2021 | SC Paderborn 07 | - | SV Darmstadt 98 | 0:1 | ||||
| 25. Round | 04/03/2022 | Holstein Kiel | - | SC Paderborn 07 | 3:4 | ||||
| 31. Round | 24/04/2022 | SC Paderborn 07 | - | Hannover 96 | 3:0 |  |
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| 32. Round | 30/04/2022 | Hansa Rostock | - | SC Paderborn 07 | 0:0 | ||||
| 34. Round | 15/05/2022 | SV Darmstadt 98 | - | SC Paderborn 07 | 3:0 |
Ghana