| 1. Round | 07/08/2021 | RFCU Luxemburg | - | Swift Hesperange | 0:3 | ||||
| 2. Round | 15/08/2021 | Swift Hesperange | - | Union Titus Pétange | 0:2 | ||||
| 4. Round | 28/08/2021 | Swift Hesperange | - | Etzella Ettelbruck | 5:2 | ||||
| 5. Round | 12/09/2021 | FC Differdange 03 | - | Swift Hesperange | 0:0 | ||||
| 6. Round | 18/09/2021 | Swift Hesperange | - | Victoria Rosport | 1:1 | ||||
| 7. Round | 22/09/2021 | CS FOLA Esch | - | Swift Hesperange | 2:1 | ||||
| 9. Round | 17/10/2021 | Swift Hesperange | - | Progrès Niedercorn | 1:1 | ||||
| 10. Round | 24/10/2021 | FC Rodange 91 | - | Swift Hesperange | 2:3 |  |
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| 20. Round | 06/03/2022 | Victoria Rosport | - | Swift Hesperange | 0:4 | ||||
| 21. Round | 13/03/2022 | Swift Hesperange | - | CS FOLA Esch | 1:1 | ||||
| 22. Round | 20/03/2022 | UNA Strassen | - | Swift Hesperange | 0:2 | ||||
| 23. Round | 02/04/2022 | Progrès Niedercorn | - | Swift Hesperange | 2:2 | |
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| 24. Round | 10/04/2022 | Swift Hesperange | - | FC Rodange 91 | 2:0 | ||||
| 26. Round | 24/04/2022 | Swift Hesperange | - | FC Wiltz 71 | 3:2 | ||||
| 27. Round | 01/05/2022 | F91 Dudelange | - | Swift Hesperange | 1:0 | ||||
| 28. Round | 08/05/2022 | Swift Hesperange | - | Jeunesse Esch | 1:1 |
Luxembourg