| 5. Round | 18/09/2021 | AFC Ajax | - | SC Cambuur | 9:0 | ||||
| 6. Round | 21/09/2021 | Fortuna Sittard | - | AFC Ajax | 0:5 | ||||
| 9. Round | 16/10/2021 | sc Heerenveen | - | AFC Ajax | 0:2 | ||||
| 18. Round | 22/12/2021 | AFC Ajax | - | Fortuna Sittard | 5:0 | ||||
| 19. Round | 16/01/2022 | FC Utrecht | - | AFC Ajax | 0:3 | ||||
| 21. Round | 06/02/2022 | AFC Ajax | - | Heracles Almelo | 3:0 |  |
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| 28. Round | 02/04/2022 | FC Groningen | - | AFC Ajax | 1:3 | ||||
| 29. Round | 09/04/2022 | AFC Ajax | - | Sparta Rotterdam | 2:1 | ||||
| 30. Round | 23/04/2022 | NEC Nijmegen | - | AFC Ajax | 0:1 | ||||
| 31. Round | 30/04/2022 | AFC Ajax | - | PEC Zwolle | 3:0 | ||||
| 32. Round | 08/05/2022 | AZ Alkmaar | - | AFC Ajax | 2:2 | ||||
| 33. Round | 11/05/2022 | AFC Ajax | - | sc Heerenveen | 5:0 | ||||
| 34. Round | 15/05/2022 | Vitesse | - | AFC Ajax | 2:2 |
Netherlands